产品名称
Dexras2 Rabbit Polyclonal Antibody
别名
RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2
蛋白名称
GTP-binding protein Rhes
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23551
Human Swissprot No.
Q96D21
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96D21/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75141
Mouse Swissprot No.
P63032
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63032
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171099
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63033
免疫原
The antiserum was produced against synthesized peptide derived from human RASD2. AA range:217-266
特异性
Dexras2 Polyclonal Antibody detects endogenous levels of Dexras2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016],
组织表达
Pancreatic endocrine cells (islets of Langerhans).
细胞定位
Cell membrane ; Lipid-anchor .
功能
function:Binds to GTP and possesses intrinsic GTPase activity. May play a role in mediating signal transduction (By similarity). May be involved in mediating the insulin secretory response to efaroxan.,similarity:Belongs to the small GTPase superfamily. RasD family.,subunit:Monomer .,tissue specificity:Pancreatic endocrine cells (islets of Langerhans).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
