产品名称
DGK-κ Rabbit Polyclonal Antibody
别名
DGKK; Diacylglycerol kinase kappa; DAG kinase kappa; 142 kDa diacylglycerol kinase; Diglyceride kinase kappa; DGK-kappa
蛋白名称
Diacylglycerol kinase kappa
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=139189
Human Swissprot No.
Q5KSL6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5KSL6/entry
免疫原
The antiserum was produced against synthesized peptide derived from human DGKK. AA range:1221-1270
特异性
DGK-κ Polyclonal Antibody detects endogenous levels of DGK-κ protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011],
组织表达
Expressed in testis, and to a lesser extent in placenta.
细胞定位
Cell membrane ; Peripheral membrane protein .
功能
catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,enzyme regulation:Inhibited in response to H(2)O(2).,function:Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).,PTM:Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 1 PH domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Does not form homooligomers.,tissue specificity:Expressed in testis, and to a lesser extent in placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
