BD-PT1318

DDX8 Rabbit Polyclonal Antibody

DHX8; DDX8; ATP-dependent RNA helicase DHX8; DEAH box protein 8; RNA helicase HRH1

常规抗体

DHX8

ATP-dependent RNA helicase DHX8

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1659

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1659

Q14562

http://www.uniprot.org/uniprotkb/Q14562/entry

217207

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=217207

A2A4P0

http://www.uniprot.org/uniprot/A2A4P0

The antiserum was produced against synthesized peptide derived from human DHX8. AA range:391-440

DDX8 Polyclonal Antibody detects endogenous levels of DDX8 protein.

WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

150kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],

Expressed in skin, cervix and nerve. Also expressed in the brain.

Nucleus .

Spliceosome;

domain:The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome.,function:Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.,similarity:Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 S1 motif domain.,subunit:Identified in the spliceosome C complex, at least composed of AQR, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRNP200, SNRNP40, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, XAB2 and ZCCHC8.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.