产品名称
DBP Rabbit Polyclonal Antibody
别名
GC; Vitamin D-binding protein; DBP; VDB; Gc-globulin; Group-specific component
蛋白名称
Vitamin D-binding protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2638
Human Swissprot No.
P02774
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P02774/entry
Mouse Swissprot No.
P21614
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P21614
免疫原
Synthesized peptide derived from DBP . at AA range: 90-170
特异性
DBP Polyclonal Antibody detects endogenous levels of DBP protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011],
组织表达
Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
功能
function:Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.,polymorphism:Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele.,similarity:Belongs to the ALB/AFP/VDB family.,similarity:Contains 3 albumin domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.