产品名称
UBP4 Rabbit Polyclonal Antibody
别名
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.269% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7375
Human Swissprot No.
Q13107
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13107/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22258
Mouse Swissprot No.
P35123
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P35123
Rat Gene Link
https://www.uniprot.org/uniprot/290864
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B2GUZ1
免疫原
Synthesized peptide derived from human UBP4 AA range: 155-205
特异性
This antibody detects endogenous levels of UBP4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
细胞定位
Cytoplasm . Nucleus . Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
