产品名称
D1DR Rabbit Polyclonal Antibody
别名
DRD1; D(1A) dopamine receptor; Dopamine D1 receptor
蛋白名称
D(1A) dopamine receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1812
Human Swissprot No.
P21728
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P21728/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13488
Mouse Swissprot No.
Q61616
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61616
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24316
Rat Swissprot Link
http://www.uniprot.org/uniprot/P18901
免疫原
The antiserum was produced against synthesized peptide derived from human DRD1. AA range:135-184
特异性
D1DR Polyclonal Antibody detects endogenous levels of D1DR protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008],
组织表达
Detected in caudate, nucleus accumbens and in the olfactory tubercle.
细胞定位
Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. .
信号通路
Calcium;Neuroactive ligand-receptor interaction;Gap junction;
功能
function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.,subunit:Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.,tissue specificity:Detected in caudate, nucleus accumbens and in the olfactory tubercle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
