产品名称
Cytokeratin 15 Rabbit Polyclonal Antibody
别名
KRT15; KRTB; Keratin; type I cytoskeletal 15; Cytokeratin-15; CK-15; Keratin-15; K15
蛋白名称
Keratin type I cytoskeletal 15
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3866
Human Swissprot No.
P19012
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P19012/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16665
Mouse Swissprot No.
Q61414
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61414
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287700
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6IFV3
免疫原
The antiserum was produced against synthesized peptide derived from human Keratin 15. AA range:1-50
特异性
Cytokeratin 15 Polyclonal Antibody detects endogenous levels of Cytokeratin 15 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008],
组织表达
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.
细胞定位
nucleus,intermediate filament,extracellular exosome,
功能
miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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