BD-PT1260

Cytokeratin 13 Rabbit Polyclonal Antibody

KRT13; Keratin; type I cytoskeletal 13; Cytokeratin-13; CK-13; Keratin-13; K13

常规抗体

KRT13

Keratin type I cytoskeletal 13

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3860

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3860

P13646

http://www.uniprot.org/uniprotkb/P13646/entry

16663

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16663

P08730

http://www.uniprot.org/uniprot/P08730

287699

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287699

Q6IFV4

http://www.uniprot.org/uniprot/Q6IFV4

The antiserum was produced against synthesized peptide derived from human Cytokeratin 13. AA range:233-282

Cytokeratin 13 Polyclonal Antibody detects endogenous levels of Cytokeratin 13 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

52kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008],

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

nucleus,intermediate filament,keratin filament,intermediate filament cytoskeleton,extracellular exosome,

disease:Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-13 entry,PTM:O-glycosylated; glycans consist of single N-acetylglucosamine residues.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.,tissue specificity:Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.