产品名称
Cytochrome b5 Rabbit Polyclonal Antibody
别名
CYB5A; CYB5; Cytochrome b5; Microsomal cytochrome b5 type A; MCB5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1528
Human Swissprot No.
P00167
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P00167/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109672
Mouse Swissprot No.
P56395
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56395
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64001
Rat Swissprot Link
http://www.uniprot.org/uniprot/P00173
免疫原
The antiserum was produced against synthesized peptide derived from human CYB5. AA range:61-110
特异性
Cytochrome b5 Polyclonal Antibody detects endogenous levels of Cytochrome b5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
组织表达
Erythrocyte,Liver,Spleen,Uterus,
细胞定位
[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.; [Isoform 2]: Cytoplasm.
功能
disease:Defects in CYB5A are the cause of type IV hereditary methemoglobinemia [MIM:250790].,function:Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.,similarity:Belongs to the cytochrome b5 family.,similarity:Contains 1 cytochrome b5 heme-binding domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
