产品名称
CYP4A11/22 Rabbit Polyclonal Antibody
别名
CYP4A11; CYP4A2; Cytochrome P450 4A11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; CYP4A22; C
蛋白名称
Cytochrome P450 4A11/22
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
1579/284541
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1579
Human Swissprot No.
Q02928/Q5TCH4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02928/entry
免疫原
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4A11/22. AA range:391-440
特异性
CYP4A11/22 Polyclonal Antibody detects endogenous levels of CYP4A11/22 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
cytochrome P450 family 4 subfamily A member 11(CYP4A11) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
组织表达
Expressed in liver (PubMed:7679927). Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572).
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
信号通路
Fatty acid metabolism;Arachidonic acid metabolism;Retinol metabolism;PPAR;Vascular smooth muscle contraction;
功能
catalytic activity:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.,cofactor:Heme group.,function:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).,online information:CYP4A11 alleles,polymorphism:CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Kidney and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
