产品名称
CYP3A43 Rabbit Polyclonal Antibody
别名
CYP3A43; Cytochrome P450 3A43
蛋白名称
Cytochrome P450 3A43
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64816
Human Swissprot No.
Q9HB55
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HB55/entry
免疫原
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 3A43. AA range:231-280
特异性
CYP3A43 Polyclonal Antibody detects endogenous levels of CYP3A43 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
cytochrome P450 family 3 subfamily A member 43(CYP3A43) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
组织表达
Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
细胞定位
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
信号通路
Steroid hormone biosynthesis;Linoleic acid metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;Drug metabolism;
功能
alternative products:Additional isoforms seem to exist,catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Exhibits low testosterone 6-beta-hydroxylase activity.,induction:By rifampicin.,online information:CYP3A43 alleles,polymorphism:At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
