BD-PT1227

CYP39A1 Rabbit Polyclonal Antibody

CYP39A1; 24-hydroxycholesterol 7-alpha-hydroxylase; Cytochrome P450 39A1; hCYP39A1; Oxysterol 7-alpha-hydroxylase

常规抗体

CYP39A1

24-hydroxycholesterol 7-alpha-hydroxylase

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

51302

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51302

Q9NYL5

http://www.uniprot.org/uniprotkb/Q9NYL5/entry

Q9JKJ9

http://www.uniprot.org/uniprot/Q9JKJ9

Synthesized peptide derived from the Internal region of human CYP39A1.

CYP39A1 Polyclonal Antibody detects endogenous levels of CYP39A1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

55kD

-20°C/1 year

Polyclonal, Rabbit,IgG

cytochrome P450 family 39 subfamily A member 1(CYP39A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Liver specific.

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .

Primary bile acid biosynthesis;

catalytic activity:(24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) = (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.,cofactor:Heme group.,function:Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Liver specific.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.