产品名称
CYP2S1 Rabbit Polyclonal Antibody
别名
CYP2S1; Cytochrome P450 2S1; CYPIIS1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29785
Human Swissprot No.
Q96SQ9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96SQ9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74134
Mouse Swissprot No.
Q9DBX6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBX6
免疫原
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230
特异性
CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
信号通路
Metabolism of xenobiotics by cytochrome P450;
功能
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
