BD-PT1199

CYP26A1 Rabbit Polyclonal Antibody

CYP26A1; CYP26; P450RAI1; Cytochrome P450 26A1; Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome

常规抗体

CYP26A1

Cytochrome P450 26A1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1592

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1592

O43174

http://www.uniprot.org/uniprotkb/O43174/entry

13082

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13082

O55127

http://www.uniprot.org/uniprot/O55127

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 26A1. AA range:251-300

CYP26A1 Polyclonal Antibody detects endogenous levels of CYP26A1 protein.

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

56kD

-20°C/1 year

Polyclonal, Rabbit,IgG

cytochrome P450 family 26 subfamily A member 1(CYP26A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],

Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557). Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119).

Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.

Retinol metabolism;

cofactor:Heme group.,function:Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.