产品名称
SNX13 Rabbit Polyclonal Antibody
别名
Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.277% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23161
Human Swissprot No.
Q9Y5W8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5W8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/217463
Mouse Swissprot No.
Q6PHS6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PHS6
免疫原
Synthesized peptide derived from human SNX13 AA range: 602-652
特异性
This antibody detects endogenous levels of SNX13 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008],
组织表达
Amygdala,Brain,Placenta,Testis,
细胞定位
Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
function:May be involved in several stages of intracellular trafficking. Act as a GAP for Galphas.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 1 PXA domain.,similarity:Contains 1 RGS domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
