产品名称
Cyclin M2 Rabbit Polyclonal Antibody
别名
CNNM2; ACDP2; Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2
蛋白名称
Metal transporter CNNM2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54805
Human Swissprot No.
Q9H8M5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H8M5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94219
Mouse Swissprot No.
Q3TWN3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TWN3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294014
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5U2P1
免疫原
The antiserum was produced against synthesized peptide derived from human CNNM2. AA range:571-620
特异性
Cyclin M2 Polyclonal Antibody detects endogenous levels of Cyclin M2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
cyclin and CBS domain divalent metal cation transport mediator 2(CNNM2) Homo sapiens This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
组织表达
Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).,miscellaneous:Shares weak sequence similarity with the cyclin family, explaining its name. However it has no cyclin-like function in vivo.,similarity:Belongs to the ACDP family.,similarity:Contains 2 CBS domains.,tissue specificity:Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
