产品名称
Cyclin G Rabbit Polyclonal Antibody
别名
CCNG1; CCNG; CYCG1; Cyclin-G1; Cyclin-G
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=900
Human Swissprot No.
P51959
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51959/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12450
Mouse Swissprot No.
P51945
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51945
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25405
Rat Swissprot Link
http://www.uniprot.org/uniprot/P39950
免疫原
The antiserum was produced against synthesized peptide derived from human Cyclin G. AA range:161-210
特异性
Cyclin G Polyclonal Antibody detects endogenous levels of Cyclin G protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],
组织表达
High levels in skeletal muscle, ovary, kidney and colon.
细胞定位
Nucleus . DNA replication foci after DNA damage.
功能
developmental stage:Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.,function:May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.,induction:Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.,similarity:Belongs to the cyclin family. Cyclin G subfamily.,subcellular location:DNA replication foci after DNA damage.,tissue specificity:High levels in skeletal muscle, ovary, kidney and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
