产品名称
Cyclin D3 Rabbit Polyclonal Antibody
别名
CCND3; G1/S-specific cyclin-D3
蛋白名称
G1/S-specific cyclin-D3
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=896
Human Swissprot No.
P30281
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30281/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12445
Mouse Swissprot No.
P30282
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30282
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25193
Rat Swissprot Link
http://www.uniprot.org/uniprot/P48961
免疫原
The antiserum was produced against synthesized peptide derived from human Cyclin D3. AA range:243-292
特异性
Cyclin D3 Polyclonal Antibody detects endogenous levels of Cyclin D3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
组织表达
Brain,Lung,Placenta,Synovial membrane tissue,Umbilical cord blood,
细胞定位
Nucleus . Cytoplasm .
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;p53;WNT;WNT-T CELLFocal adhesion;Jak_STAT;
功能
function:Essential for the control of the cell cycle at the G1/S (start) transition. Potentiates the transcriptional activity of ATF5.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin D subfamily.,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
