产品名称
Cyclin D2 Rabbit Polyclonal Antibody
别名
CCND2; G1/S-specific cyclin-D2
蛋白名称
G1/S-specific cyclin-D2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=894
Human Swissprot No.
P30279
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30279/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12444
Mouse Swissprot No.
P30280
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30280
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64033
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q04827
免疫原
The antiserum was produced against synthesized peptide derived from human CCND2. AA range:240-289
特异性
Cyclin D2 Polyclonal Antibody detects endogenous levels of Cyclin D2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencep
组织表达
Bone marrow,Heart,Placenta,Uterus,
细胞定位
Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. .; [Isoform 2]: Cytoplasm .
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;p53;WNT;WNT-T CELLFocal adhesion;Jak_STAT;
功能
function:Essential for the control of the cell cycle at the G1/S (start) transition.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin D subfamily.,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
