产品名称
CtBP2 Rabbit Polyclonal Antibody
别名
CTBP2; C-terminal-binding protein 2; CtBP2
蛋白名称
C-terminal-binding protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1488
Human Swissprot No.
P56545
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P56545/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13017
Mouse Swissprot No.
P56546
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56546
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81717
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9EQH5
免疫原
The antiserum was produced against synthesized peptide derived from human CtBP2. AA range:396-445
特异性
CtBP2 Polyclonal Antibody detects endogenous levels of CtBP2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014],
组织表达
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
细胞定位
Nucleus . Cell junction, synapse .
信号通路
WNT;WNT-T CELLNotch;Pathways in cancer;Chronic myeloid leukemia;
功能
function:Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR at Thr-179; Ser-181 and Ser-185. Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 (By similarity). Interacts with PNN, NRIP1 and WIZ.,tissue specificity:Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
