产品名称
CtBP1 Rabbit Polyclonal Antibody
别名
CTBP1; CTBP; C-terminal-binding protein 1; CtBP1
蛋白名称
C-terminal-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1487
Human Swissprot No.
Q13363
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13363/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13016
Mouse Swissprot No.
O88712
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88712
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29382
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2F5
免疫原
The antiserum was produced against synthesized peptide derived from human CtBP1. AA range:388-437
特异性
CtBP1 Polyclonal Antibody detects endogenous levels of CtBP1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],
组织表达
Expressed in germinal center B-cells.
细胞定位
Cytoplasm . Nucleus .
信号通路
WNT;WNT-T CELLNotch;Pathways in cancer;Chronic myeloid leukemia;
功能
cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.,function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.,PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA).,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2, HDAC4, HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity). Interacts with FOXP1, HIPK2, PNN and NRIP1. Interacts with ZFHX1B and WIZ. Interacts with Epstein-Barr virus EBNA3 and EBNA6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
