产品名称
C-TAK1 Rabbit Polyclonal Antibody
别名
MARK3; CTAK1; EMK2; MAP/microtubule affinity-regulating kinase 3; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Par-1a; Serine/threonine-protein kinase p78
蛋白名称
MAP/microtubule affinity-regulating kinase 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4140
Human Swissprot No.
P27448
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P27448/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17169
Mouse Swissprot No.
Q03141
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q03141
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170577
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8VHF0
免疫原
The antiserum was produced against synthesized peptide derived from human MARK3. AA range:1-50
特异性
C-TAK1 Polyclonal Antibody detects endogenous levels of C-TAK1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
microtubule affinity regulating kinase 3(MARK3) Homo sapiens The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
细胞定位
Cell membrane ; Peripheral membrane protein . Cell projection, dendrite . Cytoplasm .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,similarity:Contains 1 KA1 (kinase-associated) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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