产品名称
CstF-50 Rabbit Polyclonal Antibody
别名
CSTF1; Cleavage stimulation factor subunit 1; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; CSTF 50 kDa subunit; CstF-50
蛋白名称
Cleavage stimulation factor subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1477
Human Swissprot No.
Q05048
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q05048/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67337
Mouse Swissprot No.
Q99LC2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99LC2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311670
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5BJQ6
免疫原
The antiserum was produced against synthesized peptide derived from human CSTF1. AA range:1-50
特异性
CstF-50 Polyclonal Antibody detects endogenous levels of CstF-50 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],
功能
domain:N-terminus mediates homodimerization.,domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.,function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.,PTM:The N-terminus is blocked.,similarity:Contains 6 WD repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
