产品名称
CSP Rabbit Polyclonal Antibody
别名
DNAJC5; CSP; DnaJ homolog subfamily C member 5; Cysteine string protein; CSP
蛋白名称
DnaJ homolog subfamily C member 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80331
Human Swissprot No.
Q9H3Z4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H3Z4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13002
Mouse Swissprot No.
P60904
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P60904
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79130
Rat Swissprot Link
http://www.uniprot.org/uniprot/P60905
免疫原
The antiserum was produced against synthesized peptide derived from human DNAJC5. AA range:131-180
特异性
CSP Polyclonal Antibody detects endogenous levels of CSP protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010],
组织表达
Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
细胞定位
Cytoplasm, cytosol . Membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane . Melanosome . Cell membrane . The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
功能
function:May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,similarity:Contains 1 J domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
