产品名称
CSN3 Rabbit Polyclonal Antibody
别名
COPS3; CSN3; COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3; JAB1-containing signalosome subunit 3
蛋白名称
COP9 signalosome complex subunit 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8533
Human Swissprot No.
Q9UNS2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UNS2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26572
Mouse Swissprot No.
O88543
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88543
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287367
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q68FW9
免疫原
The antiserum was produced against synthesized peptide derived from human JAB1. AA range:374-423
特异性
CSN3 Polyclonal Antibody detects endogenous levels of CSN3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
组织表达
Widely expressed. Expressed at high level in heart and skeletal muscle.
细胞定位
Cytoplasm . Nucleus .
功能
function:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.,miscellaneous:Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CSN3 family.,similarity:Contains 1 PCI domain.,subunit:Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.,tissue specificity:Widely expressed. Expressed at high level in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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