BD-PT1115

CRMP-2 Rabbit Polyclonal Antibody

DPYSL2; CRMP2; ULIP2; Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2

常规抗体

DPYSL2

Dihydropyrimidinase-related protein 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1808

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1808

Q16555

http://www.uniprot.org/uniprotkb/Q16555/entry

12934

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12934

O08553

http://www.uniprot.org/uniprot/O08553

25416

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25416

P47942

http://www.uniprot.org/uniprot/P47942

The antiserum was produced against synthesized peptide derived from human DRP-2. AA range:480-529

CRMP-2 Polyclonal Antibody detects endogenous levels of CRMP-2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

62kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],

Ubiquitous.

Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Membrane . Tightly but non-covalently associated with membranes.

Axon guidance;

function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.