产品名称
CRF-RII Rabbit Polyclonal Antibody
别名
CRHR2; CRF2R; CRH2R; Corticotropin-releasing factor receptor 2; CRF-R-2; CRF-R2; CRFR-2; Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2
蛋白名称
Corticotropin-releasing factor receptor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1395
Human Swissprot No.
Q13324
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13324/entry
Mouse Swissprot No.
Q60748
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60748
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64680
Rat Swissprot Link
http://www.uniprot.org/uniprot/P47866
免疫原
The antiserum was produced against synthesized peptide derived from human CRHR2. AA range:71-120
特异性
CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],
组织表达
Amygdala,Brain,Skeletal muscle,
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
