产品名称
CREM Rabbit Polyclonal Antibody
别名
CREM; cAMP-responsive element modulator; Inducible cAMP early repressor; ICER
蛋白名称
cAMP-responsive element modulator
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1390
Human Swissprot No.
Q03060
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q03060/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12916
Mouse Swissprot No.
P27699
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P27699
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25620
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q03061
免疫原
The antiserum was produced against synthesized peptide derived from human CREM. AA range:81-130
特异性
CREM Polyclonal Antibody detects endogenous levels of CREM protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
cAMP responsive element modulator(CREM) Homo sapiens This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008],
组织表达
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
细胞定位
Nucleus.; [Isoform 6]: Cytoplasm . Nucleus .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.,PTM:Stimulated by phosphorylation.,sequence caution:Translated as Tyr.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Binds DNA as a dimer. Interacts with FHL5.,tissue specificity:Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
