BD-PT1104

CREB3L2 Rabbit Polyclonal Antibody

CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7

常规抗体

CREB3L2

Cyclic AMP-responsive element-binding protein 3-like protein 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

64764

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64764

Q70SY1

http://www.uniprot.org/uniprotkb/Q70SY1/entry

208647

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208647

Q8BH52

http://www.uniprot.org/uniprot/Q8BH52

362339

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362339

Q6QDP7

http://www.uniprot.org/uniprot/Q6QDP7

The antiserum was produced against synthesized peptide derived from human CREB3L2. AA range:269-318

CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

58kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.

Endoplasmic reticulum membrane ; Single-pass type II membrane protein. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Upon ER stress, translocated into the nucleus. .

Melanogenesis;Huntington's disease;Prostate cancer;

disease:A chromosomal rearrangement involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.,function:Transcriptional activator that may act during endoplasmic reticulum stress late phase by activating unfolded protein response target genes. May play a role in preventing accumulation of unfolded proteins in damaged neurons. In vitro, binds to the cAMP response element (CRE) and activates transcription through CRE.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Binds DNA as a dimer.,tissue specificity:Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.