BD-PT1102

CREB-2 Rabbit Polyclonal Antibody

ATF4; CREB2; TXREB; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding prot

常规抗体

ATF4

Cyclic AMP-dependent transcription factor ATF-4

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

468

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=468

P18848

http://www.uniprot.org/uniprotkb/P18848/entry

11911

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11911

Q06507

http://www.uniprot.org/uniprot/Q06507

Synthesized peptide derived from CREB-2 . at AA range: 160-240

CREB-2 Polyclonal Antibody detects endogenous levels of CREB-2 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

38kD

-20°C/1 year

Polyclonal, Rabbit,IgG

activating transcription factor 4(ATF4) Homo sapiens This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provid

Bladder,Colon,Fibroblast,Leukemic T-cell,Lung,Ovary,Placenta,

Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .

MAPK_ERK_Growth;MAPK_G_Protein;Long-term potentiation;Neurotrophin;GnRH;Prostate cancer;

function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.