产品名称
Creatine Kinase M Rabbit Polyclonal Antibody
别名
CKM; CKMM; Creatine kinase M-type; Creatine kinase M chain; M-CK
蛋白名称
Creatine kinase M-type
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1158
Human Swissprot No.
P06732
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P06732/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12715
Mouse Swissprot No.
P07310
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07310
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24265
Rat Swissprot Link
http://www.uniprot.org/uniprot/P00564
免疫原
The antiserum was produced against synthesized peptide derived from human M-CK. AA range:10-59
特异性
Creatine Kinase M Polyclonal Antibody detects endogenous levels of Creatine Kinase M protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008],
信号通路
Arginine and proline metabolism;
功能
catalytic activity:ATP + creatine = ADP + phosphocreatine.,function:Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.,online information:CKM entry,online information:Creatine kinase entry,similarity:Belongs to the ATP:guanido phosphotransferase family.,subunit:Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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