产品名称
CRABP-II Rabbit Polyclonal Antibody
别名
CRABP2; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II
蛋白名称
Cellular retinoic acid-binding protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1382
Human Swissprot No.
P29373
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P29373/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12904
Mouse Swissprot No.
P22935
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P22935
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911902
Rat Swissprot Link
http://www.uniprot.org/uniprot/P51673
免疫原
The antiserum was produced against synthesized peptide derived from human CRABP2. AA range:41-90
特异性
CRABP-II Polyclonal Antibody detects endogenous levels of CRABP-II protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010],
细胞定位
Cytoplasm. Endoplasmic reticulum. Nucleus. Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
功能
domain:Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.,function:Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.,induction:By retinoic acid.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,subcellular location:Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.,subunit:Interacts with RXR and RARA (By similarity). Interacts with importin alpha.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
