产品名称
CPZ Rabbit Polyclonal Antibody
别名
CPZ; Carboxypeptidase Z; CPZ
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8532
Human Swissprot No.
Q66K79
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q66K79/entry
Mouse Swissprot No.
Q8R4V4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4V4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83575
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54858
免疫原
Synthesized peptide derived from CPZ . at AA range: 330-410
特异性
CPZ Polyclonal Antibody detects endogenous levels of CPZ protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
carboxypeptidase Z(CPZ) Homo sapiens This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA.,function:Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.,similarity:Belongs to the peptidase M14 family.,similarity:Contains 1 FZ (frizzled) domain.,tissue specificity:In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
