产品名称
CPM Rabbit Polyclonal Antibody
别名
CPM; Carboxypeptidase M; CPM
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1368
Human Swissprot No.
P14384
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P14384/entry
Mouse Swissprot No.
Q80V42
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80V42
免疫原
The antiserum was produced against synthesized peptide derived from human CPM. AA range:71-120
特异性
CPM Polyclonal Antibody detects endogenous levels of CPM protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
carboxypeptidase M(CPM) Homo sapiens The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Liver,Lung,Placenta,
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor .
功能
catalytic activity:Cleavage of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Inhibited by O-phenanthroline and MGTA and activated by cobalt.,function:Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.,similarity:Belongs to the peptidase M14 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
