产品名称
cPLA2-γ Rabbit Polyclonal Antibody
别名
PLA2G4C; Cytosolic phospholipase A2 gamma; cPLA2-gamma; Phospholipase A2 group IVC
蛋白名称
Cytosolic phospholipase A2 gamma
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8605
Human Swissprot No.
Q9UP65
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UP65/entry
免疫原
The antiserum was produced against synthesized peptide derived from human PLA2G4C. AA range:301-350
特异性
cPLA2-γ Polyclonal Antibody detects endogenous levels of cPLA2-γ protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],
组织表达
Highly expressed in heart and skeletal muscle.
细胞定位
Cell membrane ; Lipid-anchor . Endoplasmic reticulum membrane ; Lipid-anchor. Mitochondrion membrane ; Lipid-anchor. Lipid droplet . Translocates from endoplasmic reticulum to lipid droplets in response to oleate. .
功能
catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,enzyme regulation:Not regulated by calcium.,function:Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.,similarity:Contains 1 PLA2c domain.,tissue specificity:Highly expressed in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
