产品名称
S26A8 Rabbit Polyclonal Antibody
别名
Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.284% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/116369
Human Swissprot No.
Q96RN1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96RN1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
Q8R0C3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0C3
免疫原
Synthesized peptide derived from human S26A8 AA range: 82-132
特异性
This antibody detects endogenous levels of S26A8 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010],
组织表达
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.
细胞定位
Membrane ; Multi-pass membrane protein . Located at the annulus ring structure within the sperm cell. .
功能
caution:Was originally (Ref.3, AAO26699) thought to originate from mouse.,function:Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility.,induction:Repressed by tunicamycin, an inhibitor of N-glycosylation.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters), gluconate, and by thiosulfate.,PTM:N-glycosylated.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 STAS domain.,subcellular location:Located at the annulus ring structure within the sperm cell.,subunit:Interacts with RACGAP1.,tissue specificity:Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
