产品名称
CPI-17 Rabbit Polyclonal Antibody
别名
PPP1R14A; CPI17; PPP1INL; Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
蛋白名称
Protein phosphatase 1 regulatory subunit 14A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94274
Human Swissprot No.
Q96A00
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96A00/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68458
Mouse Swissprot No.
Q91VC7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91VC7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114004
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99MC0
免疫原
The antiserum was produced against synthesized peptide derived from human CPI17 alpha. AA range:5-54
特异性
CPI-17 Polyclonal Antibody detects endogenous levels of CPI-17 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011],
组织表达
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
信号通路
Vascular smooth muscle contraction;
功能
function:Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
