产品名称
COX6c Rabbit Polyclonal Antibody
别名
COX6C; Cytochrome c oxidase subunit 6C; Cytochrome c oxidase polypeptide VIc
蛋白名称
Cytochrome c oxidase subunit 6C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1345
Human Swissprot No.
P09669
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09669/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12864
Mouse Swissprot No.
Q9CPQ1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CPQ1
免疫原
The antiserum was produced against synthesized peptide derived from human COX6C. AA range:11-60
特异性
COX6c Polyclonal Antibody detects endogenous levels of COX6c protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010],
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein .
信号通路
Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;
功能
function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase subunit 6c family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
