产品名称
COX5a Rabbit Polyclonal Antibody
别名
COX5A; Cytochrome c oxidase subunit 5A; mitochondrial; Cytochrome c oxidase polypeptide Va
蛋白名称
Cytochrome c oxidase subunit 5A mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9377
Human Swissprot No.
P20674
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20674/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12858
Mouse Swissprot No.
P12787
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P12787
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=252934
Rat Swissprot Link
http://www.uniprot.org/uniprot/P11240
免疫原
Synthesized peptide derived from COX5a . at AA range: 40-120
特异性
COX5a Polyclonal Antibody detects endogenous levels of COX5a protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008],
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
信号通路
Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;
功能
function:This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase subunit 5A family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
