产品名称
COX4I2 Rabbit Polyclonal Antibody
别名
COX4I2; COX4L2; Cytochrome c oxidase subunit 4 isoform 2; mitochondrial; Cytochrome c oxidase subunit IV isoform 2; COX IV-2
蛋白名称
Cytochrome c oxidase subunit 4 isoform 2 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84701
Human Swissprot No.
Q96KJ9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96KJ9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84682
Mouse Swissprot No.
Q91W29
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91W29
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84683
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q91Y94
免疫原
The antiserum was produced against synthesized peptide derived from human COX42. AA range:31-80
特异性
COX4I2 Polyclonal Antibody detects endogenous levels of COX4I2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in lung.
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein .
信号通路
Oxidative phosphorylation;Cardiac muscle contraction;Alzheimer's disease;Parkinson's disease;Huntington's disease;
功能
function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Highly expressed in lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
