产品名称
COX11 Rabbit Polyclonal Antibody
别名
COX11; Cytochrome c oxidase assembly protein COX11; mitochondrial
蛋白名称
Cytochrome c oxidase assembly protein COX11 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1353
Human Swissprot No.
Q9Y6N1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y6N1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69802
Mouse Swissprot No.
Q6P8I6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6P8I6
免疫原
The antiserum was produced against synthesized peptide derived from human COX11. AA range:51-100
特异性
COX11 Polyclonal Antibody detects endogenous levels of COX11 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to c
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .
信号通路
Oxidative phosphorylation;
功能
function:Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.,similarity:Belongs to the COX11/ctaG family.,subunit:Interacts with CNNM4/ACDP4.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
