产品名称
Coronin 1A Rabbit Polyclonal Antibody
别名
CORO1A; CORO1; Coronin-1A; Coronin-like protein A; Clipin-A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein; TACO
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11151
Human Swissprot No.
P31146
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P31146/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12721
Mouse Swissprot No.
O89053
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O89053
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155151
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q91ZN1
免疫原
Synthesized peptide derived from Coronin 1A . at AA range: 150-230
特异性
Coronin 1A Polyclonal Antibody detects endogenous levels of Coronin 1A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010],
组织表达
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle, phagosome membrane . In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). .
功能
function:May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.,similarity:Belongs to the WD repeat coronin family.,similarity:Contains 5 WD repeats.,subcellular location:In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.,subunit:Binds actin.,tissue specificity:Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
