产品名称
Connexin 47 Rabbit Polyclonal Antibody
别名
GJC2; GJA12; Gap junction gamma-2 protein; Connexin-46.6; Cx46.6; Connexin-47; Cx47; Gap junction alpha-12 protein
蛋白名称
Gap junction gamma-2 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57165
Human Swissprot No.
Q5T442
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5T442/entry
Mouse Swissprot No.
Q8BQU6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BQU6
免疫原
The antiserum was produced against synthesized peptide derived from human CXG2. AA range:21-70
特异性
Connexin 47 Polyclonal Antibody detects endogenous levels of Connexin 47 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008],
组织表达
Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
功能
caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in GJC2 are the cause of Leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins. Interacts with TJP1.,tissue specificity:Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
