BD-PT1025

COL4A2 Rabbit Polyclonal Antibody

COL4A2; Collagen alpha-2(IV) chain

常规抗体

COL4A2

Collagen alpha-2(IV) chain

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1284

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1284

P08572

http://www.uniprot.org/uniprotkb/P08572/entry

12827

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12827

P08122

http://www.uniprot.org/uniprot/P08122

The antiserum was produced against synthesized peptide derived from human Collagen IV alpha2. AA range:151-200

COL4A2 Polyclonal Antibody detects endogenous levels of COL4A2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

150kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008],

Eye,Hepatocyte,Placenta,Skin,

Secreted, extracellular space, extracellular matrix, basement membrane.

Focal adhesion;ECM-receptor interaction;Pathways in cancer;Small cell lung cancer;

domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.,similarity:Belongs to the type IV collagen family.,similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.,subunit:There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.