产品名称
COL19A1 Rabbit Polyclonal Antibody
别名
COL19A1; Collagen alpha-1(XIX) chain; Collagen alpha-1(Y) chain
蛋白名称
Collagen alpha-1(XIX) chain
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1310
Human Swissprot No.
Q14993
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14993/entry
Mouse Swissprot No.
Q0VF58
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q0VF58
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen XIX alpha1. AA range:421-470
特异性
COL19A1 Polyclonal Antibody detects endogenous levels of COL19A1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008],
组织表达
Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
domain:The numerous interruptions in the triple helix may make this molecule either elastic or flexible.,function:May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Oligomer; disulfide-linked.,tissue specificity:Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
