产品名称
CNOT7 Rabbit Polyclonal Antibody
别名
CNOT7; CAF1; CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1
蛋白名称
CCR4-NOT transcription complex subunit 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29883
Human Swissprot No.
Q9UIV1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UIV1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18983
Mouse Swissprot No.
Q60809
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60809
免疫原
The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59
特异性
CNOT7 Polyclonal Antibody detects endogenous levels of CNOT7 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
CCR4-NOT transcription complex subunit 7(CNOT7) Homo sapiens The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016],
组织表达
Embryo,Lymph,Placenta,Prostate,Testis,
细胞定位
Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .
功能
function:Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.,similarity:Belongs to the CAF1 family.,subunit:Interacts with TOB1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
