产品名称
CNOT4 Rabbit Polyclonal Antibody
别名
CNOT4; NOT4; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; Potential transcriptional repressor NOT4Hp
蛋白名称
CCR4-NOT transcription complex subunit 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4850
Human Swissprot No.
O95628
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95628/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53621
Mouse Swissprot No.
Q8BT14
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BT14
免疫原
The antiserum was produced against synthesized peptide derived from human CNOT4. AA range:61-110
特异性
CNOT4 Polyclonal Antibody detects endogenous levels of CNOT4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
CCR4-NOT transcription complex subunit 4(CNOT4) Homo sapiens The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010],
组织表达
Mammary gland,Testis,
细胞定位
Cytoplasm . Nucleus .
功能
function:Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Sequencing errors.,similarity:Contains 1 C3H1-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
