产品名称
CNK2 Rabbit Polyclonal Antibody
别名
CNKSR2; CNK2; KIAA0902; KSR2; Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; CNK homolog protein 2; CNK2
蛋白名称
Connector enhancer of kinase suppressor of ras 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22866
Human Swissprot No.
Q8WXI2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WXI2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245684
Mouse Swissprot No.
Q80YA9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80YA9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59322
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1T4
免疫原
The antiserum was produced against synthesized peptide derived from human CNKR2. AA range:641-690
特异性
CNK2 Polyclonal Antibody detects endogenous levels of CNK2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
细胞定位
Cytoplasm. Membrane; Peripheral membrane protein.
功能
function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 DUF1170 domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RAF1, RAB2L and RAL GTPase proteins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
