产品名称
RUBIC Rabbit Polyclonal Antibody
别名
Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.290% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9711
Human Swissprot No.
Q92622
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92622/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/100502698
Mouse Swissprot No.
Q80U62
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80U62
免疫原
Synthesized peptide derived from human RUBIC AA range: 868-918
特异性
This antibody detects endogenous levels of RUBIC at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
组织表达
Blood,Bone marrow,Heart,Kidney,
细胞定位
Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
功能
similarity:Contains 1 RUN domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
