产品名称
CNG-1 Rabbit Polyclonal Antibody
别名
CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel; photoreceptor; Rod photoreceptor cG
蛋白名称
cGMP-gated cation channel alpha-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1259
Human Swissprot No.
P29973
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P29973/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12788
Mouse Swissprot No.
P29974
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P29974
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85259
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62927
免疫原
The antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450
特异性
CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
组织表达
Rod cells in the retina.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
caution:It is uncertain whether Met-1 or Met-5 is the initiator.,disease:Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:Homotetramer or higher oligomer. Forms heterooligomeric complex with CNG4.,tissue specificity:Rod cells in the retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
